• Ulrik Deding, Henrik Bøggild, Gunnar Baatrup, Lasse Kaalby, Jacob Hjelmborg, Marianne Kirstine Thygesen, Benedicte Schelde-Olesen, Morten Kobaek-Larsen, and CareForColon2015 study group.
• Department of Clinical Research, University of Southern Denmark, Denmark; Department of Surgery, Odense University Hospital, Denmark. Electronic address: Ulrik.deding@rsyd.dk.
• Prev Med. 2023 Aug 1; 173: 107593107593.

AbstractIndividual income and educational level are associated with participation rates in colorectal cancer screening. We aimed to investigate the expected discomfort from the endoscopic diagnostic modalities of colonoscopy and colon capsule endoscopy in different socioeconomic groups as a potential barrier for participation. In a randomized clinical trial within the Danish colorectal cancer screening program, we distributed questionnaires to 2031 individuals between August 2020 and December 2022 to investigate the expected procedural and overall discomfort from investigations using visual analogue scales. Socioeconomic status was determined by household income and educational level. Multivariate continuous ordinal regressions were performed to estimate the odds of higher expected discomfort. The expected procedural and overall discomfort from both modalities were significantly higher with increasing educational levels and income, except for procedural discomfort from colon capsule endoscopy between income quartiles. The odds ratios for higher expected discomfort increased significantly with increasing educational level, whereas the differences between income groups were less substantial. Bowel preparation contributed most to expected discomfort in colon capsule endoscopy, whereas in colonoscopy, the procedure itself was the largest contributor. Individuals with prior experiences of colonoscopy reported significantly lower expected overall but not procedural discomfort from colonoscopy. The threshold for acceptable discomfort between subgroups is unknown, but the expected discomfort in colon capsule endoscopy and colonoscopy was higher in higher socioeconomic subgroups, suggesting that expected discomfort is not a significant contributor to the inequalities in screening uptake.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

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