• Acta clinica Croatica · Nov 2022

    IMPACT OF NEUROTROPIC VIRUSES ON SURVIVAL OF PATIENTS WITH SURGICALLY TREATED GLIOBLASTOMA.

    • Nenad Koruga, Tatjana Pekmezović, Ilijan Tomaš, Anamarija Soldo Koruga, Ksenija Marjanović, Jasmina Rajc, Ante Rotim, and Krešimir Rotim.
    • Department of Neurosurgery, University Hospital Center Osijek, Croatia, Faculty of Medicine, University of J.J. Strossmayer Osijek, Croatia.
    • Acta Clin Croat. 2022 Nov 1; 61 (3): 476481476-481.

    IntroductionGlioblastoma represents the most aggressive tumor of the brain with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two decades, many studies were conducted with the aim of confirming viral influence in the development of glioblastoma.MethodsWe conducted a retrospective study in a time period of five years using formalin-fixed paraffin-embedded tissues of glioblastoma. Immunohistochemistry was performed for three viruses: CMV, EBV and HSV-1, using an automated staining system.ResultsMean age of patients in our group was 66.7±8.5 years. A slight male dominance was noted. Negative immunohistochemistry results were obtained for CMV and EBV, which were excluded from further investigation. Based on IRS score, we confirmed six HSV-1 samples which were rated as IRS score 2. Five more samples of HSV-1 were rated as IRS score 1 and were excluded from the study.ConclusionAccording to our retrospective study and its results, we found no impact of neurotropic viruses in the survival rate of glioblastoma. Further studies should be conducted including a wider range of viral detection methods.

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