• Abayomi K Arogundade, Ademola A Popoola, Abdulwahab A Ajape, Olajide O Abiola, and Sikiru A Biliaminu.
• Federal Teaching Hospital, Urology Unit, Department of Surgery.
• Afr Health Sci. 2023 Mar 1; 23 (1): 483491483-491.

BackgroundSurgical androgen deprivation therapy (ADT) to treat advanced prostate cancer can be achieved either by bilateral total orchidectomy (BTO) or bilateral subcapsular orchidectomy (BSCO). However, biochemical and clinical equivalence between BTO and BSCO among native Africans is undocumented.ObjectiveTo compare the biochemical response (testosterone and prostate specific antigen) in patients who had BTO and BSCO for advanced prostate cancer.MethodsA randomized single- blind study of 64 consenting patients that underwent either BTO or BSCO. Pre- and post-operative PSA and testosterone assays were done serially at intervals and compared between each treatment group.ResultsEach treatment group were similar with no statistically significant difference in terms of age (p= 0.449) or degree of tumor differentiation (p =0.714). Neither median testosterone (p= 0.515) nor the mean pre-operative PSA differ between the two groups (p = 0.482). Also, similar trends were noticed post operatively except at the 2nd month when a statistically significant difference was recorded (p = 0.003).ConclusionThe two techniques of orchidectomy were effective in accomplishing androgen deprivation. They produced similar biochemical (testosterone and PSA) response.© 2023 Arogundade AK et al.

20 keywords...

hide…