• African health sciences · Mar 2023

    Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria.

    • Adebomi Funmilayo Odusanya, Gabriel Ifeoluwa Makinde, Michael Oladimeji Idowu, and Ayodeji Matthew Adebayo.
    • University College Hospital Ibadan, Department of Medical Microbiology and Parasitology.
    • Afr Health Sci. 2023 Mar 1; 23 (1): 190197190-197.

    AimHepatitis B virus HBV infection is a major cause of chronic liver disease worldwide. CD4 count and haematological parameters (HPs) could be used to monitor the health status of hepatitis B (HB) individuals. This study aimed at assessing levels of CD4 count and some HPs among sufferers of HB patients and controls.MethodsFifty (50) HB patients as cases and 50 age-matched controls were recruited into the study. 5ml of whole blood sample was collected from all eligible participants of which 20µl and 10µl were used for CD4 count and HPs analysis respectively. Pearson correlation analysis was used to assess statistical difference within them using SPSS version 20.ResultsThere was significant increase between the normal values of the CD4 count of both cases and controls (p<0.05). Significant correlations were found in some HPs such as HCT with WBC; HB and RBC with PLT; RBC, HCT and PLT with WBC.ConclusionThere were no significant differences between the values of the CD4 count and hematological parameters among HB subjects in this study. There is need for future studies to detect changes in CD4 count and other HPs in HB patients to increase options of screening for immunological changes during management.© 2023 Odusanya AF et al.

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