• Nazlim Aktug Demir, Sema Yilmaz Kirik, Sua Sumer, Onur Ural, Hatice Esranur Kiratlı, Husamettin Vatansev, Esra Paydas Hayatsal, Ugur Arslan, Hakan Cebeci, and Lutfi Saltuk Demir.
• Selcuk University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology 42250 Konya, Turkey.
• Afr Health Sci. 2023 Mar 1; 23 (1): 374337-43.

BackgroundThe progression of COVID-19 has different clinical presentations, which raises a number of immunological questions.ObjectivesThis study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involvement in COVID-19.MethodsThis study was conducted with 192 patients and 45 healthy controls. ELISA was used to measure the MMP-9 and TIMP-1.ResultsThe MMP-9 and TIMP-1 levels of the patients were found to be higher than those of the controls. MMP-9 and TIMP-1 were detected more in patients with lung involvement on chest CT scans than in those with no lung involvement on chest CT scans. A comparison of lung involvement levels revealed no difference was found between the groups. The MMP-9/TIMP-1 ratio was 5.8 in the group with lung involvement on chest CT scans and 6.1 in the group without lung involvement on chest CT scans. No difference was found between the two groups. A comparison with respect to lung involvement levels showed that the MMP-9/TIMP-1 ratio difference was found between the groups.ConclusionDiagnostic and treatment methods targeting MMP-9 activity or neutrophil activation may be important in predicting lung involvement in COVID-19 and directing clinical outcomes.© 2023 Demir NA et al.

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