• Arch Med Sci · Jan 2023

    Shared immune metabolic reprogramming between COVID-19 patients in the intensive care unit and ischemic stroke: a pilot study.

    • Jie Li, Fusheng Li, Bin He, Cong Yu, and Ping Zheng.
    • Department of Neurosurgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    • Arch Med Sci. 2023 Jan 1; 19 (6): 190419081904-1908.

    IntroductionTo investigate shared gene signatures between COVID-19 and ischemic stroke.MethodsCombining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism.ResultsA total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways.ConclusionsOur study revealed the common molecular profile of COVID-19 and ischemic stroke.Copyright: © 2023 Termedia & Banach.

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