• TokerMelike KorkmazMK0000-0003-1916-4454From the Department of Anesthesiology and Reanimation (Korkmaz Toker, Altiparmak, Ugur); from the Department of Neurosurgery (Gursoy,), Mugla Sıtkı Kocman; from the Department of Anesthesiology and Reanimation (Uysa, Basak Altiparmak, Guven Gursoy, Ali Ihsan Uysal, Gulseda Dede, Gulsah Gundogdu, Yavuz Dodurga, and Bakiye Ugur.
• From the Department of Anesthesiology and Reanimation (Korkmaz Toker, Altiparmak, Ugur); from the Department of Neurosurgery (Gursoy,), Mugla Sıtkı Kocman; from the Department of Anesthesiology and Reanimation (Uysal, Dede), Mugla Sıtkı Kocman University, Training and Research Hospital, Mugla; from the Department of Physiology (Gundogdu); and from the Department of Medical Biology (Dodurga), Medical Faculty, Pamukkale University, Denizli, Turkey.
• Saudi Med J. 2024 May 1; 45 (5): 468475468-475.

ObjectivesTo compare the genotoxic effects of desflurane and propofol using comet assay in patients undergoing elective discectomy surgery.MethodsThis was a randomized controlled study. Patients who underwent elective lumbar discectomy under general anesthesia with propofol or desflurane were included in the study. Venous blood samples were obtained at 4 different time points: 5 minutes before anesthesia induction (T1), 2 hours after the start of anesthesia (T2), the first day after surgery (T3), and the fifth day following surgery (T4). Deoxyribonucleic acid damage in lymphocytes was assessed via the comet assay.ResultsA total of 30 patients, 15 in each group, were included in the analysis. The groups were similar in terms of age and gender distribution. There were no significant differences in demographics, duration of surgery, total remifentanil consumption, and total rocuronium bromide consumption. The comet assay revealed that head length, head intensity, tail intensity, tail moment at T1 were similar in the desflurane and propofol groups. Head length, tail length and tail moment measured in the desflurane group at T4 were significantly higher compared to the propofol group. Tail lengths of the desflurane group at T1, T2 and T3 were significantly higher than the corresponding values in the propofol group.ConclusionPropofol and desflurane do not appear to induce DNA damage in lymphocytes. However, when the quantitative data were compared, it was determined that propofol had relatively lower genotoxic potential than desflurane.ClinicalTrials.gov Reg. No.: NCT05185167.Copyright: © Saudi Medical Journal.

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