• Preventive medicine · Aug 2024

    Randomized Controlled Trial

    Reducing perceived barriers to scaling up overdose education and naloxone distribution and medications for opioid use disorder in the United States in the HEALing (helping end addiction long-term®) communities study.

    • Hannah K Knudsen, Daniel M Walker, Nicole Mack, Elizabeth N Kinnard, Timothy R Huerta, LaShawn Glasgow, Louisa Gilbert, Bryan R Garner, Anindita Dasgupta, Redonna Chandler, Sharon L Walsh, Yjuliana Tin, Sylvia Tan, Joel Sprunger, Linda Sprague-Martinez, Pamela Salsberry, Merielle Saucier, Maria Rudorf, Sandra Rodriguez, Carrie B Oser, Emmanuel Oga, Julie Nakayima, Beth S Linas, R Craig Lefebvre, Sarah Kosakowski, Rachel E Katz, Timothy Hunt, Ari Holman, JaNae Holloway, Dawn Goddard-Eckrich, Naleef Fareed, Mia Christopher, Alison Aldrich, Joella W Adams, and Mari-Lynn Drainoni.
    • Department of Family and Community Medicine, Ohio State University, Suite 5000, 700 Ackerman Rd, Columbus, OH 43202, USA. Electronic address: hkknud2@uky.edu.
    • Prev Med. 2024 Aug 1; 185: 108034108034.

    BackgroundScaling up overdose education and naloxone distribution (OEND) and medications for opioid use disorder (MOUD) is needed to reduce opioid overdose deaths, but barriers are pervasive. This study examines whether the Communities That HEAL (CTH) intervention reduced perceived barriers to expanding OEND and MOUD in healthcare/behavioral health, criminal-legal, and other/non-traditional venues.MethodsThe HEALing (Helping End Addiction Long-Term®) Communities Study is a parallel, wait-list, cluster randomized trial testing the CTH intervention in 67 communities in the United States. Surveys administered to coalition members and key stakeholders measured the magnitude of perceived barriers to scaling up OEND and MOUD in November 2019-January 2020, May-June 2021, and May-June 2022. Multilevel linear mixed models compared Wave 1 (intervention) and Wave 2 (wait-list control) respondents. Interactions by rural/urban status and research site were tested.ResultsWave 1 respondents reported significantly greater reductions in mean scores for three outcomes: perceived barriers to scaling up OEND in Healthcare/Behavioral Health Venues (-0.26, 95% confidence interval, CI: -0.48, -0.05, p = 0.015), OEND in Other/Non-traditional Venues (-0.53, 95% CI: - 0.84, -0.22, p = 0.001) and MOUD in Other/Non-traditional Venues (-0.34, 95% CI: -0.62, -0.05, p = 0.020). There were significant interactions by research site for perceived barriers to scaling up OEND and MOUD in Criminal-Legal Venues. There were no significant interactions by rural/urban status.DiscussionThe CTH Intervention reduced perceived barriers to scaling up OEND and MOUD in certain venues, with no difference in effectiveness between rural and urban communities. More research is needed to understand facilitators and barriers in different venues.Copyright © 2024 Elsevier Inc. All rights reserved.

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