• Zhang Ling, Tian Qing, and Xie Chunming.
• Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Jiangsu Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
• Neuroscience. 2024 Nov 12; 560: 485548-55.

AbstractSuicide ideation (SI) is the major cause of death in persons with depression, whereas effective and accurate biomarkers for suicidal behavior of persons with depression are still lack. Recently, manifold studies in vivo revealed that epigenetic alterations including DNA methylation, non-coding RNA regulation, RNA editing and histone modification, were associated with depressive severity and SI, and peripheral epigenetic molecules may be potential biomarkers for suicidal risk of persons with depression. Therefore, we firstly reviewed recent epigenetic advancements in depression with suicide ideation (DSI) according to studies based on human tissue. Furthermore, we discussed the significance and potential of minimally-invasive peripheral epigenetic molecules to identify potential suicidal biomarkers for DSI, aiming to promote early identification and therapeutic evaluation of DSI.Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

16 keywords...

hide…