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Meta Analysis
Mendelian randomization in Alzheimer's disease and mild cognitive impairment: Hippocampal volume associations.
- Jianguo Zhou, Lei Gong, Xiaoli Liu, Liping Chen, and Zhou Yang.
- Department of Radiology, Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang 222004, PR China.
- Neuroscience. 2024 Nov 22; 561: 304230-42.
AbstractThis study investigates the association between cognitive dysfunction and hippocampal volumes in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) using Mendelian randomization. A meta-analysis of 503 healthy controls, 562 MCI patients, and 389 CE patients revealed significant reductions in hippocampal and subregion volumes in MCI and AD compared to controls. While various subregions showed volume reductions, no causal relationship between hippocampal volume and AD was established through Mendelian randomization analysis. In conclusion, significant volume reductions were observed in MCI and AD patients, highlighting the complexity of the relationship between hippocampal volume and cognitive impairment.Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.
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