• Ah-Ra Jang, Do-Hyeon Jung, Tae-Sung Lee, Jeon-Kyung Kim, Yu-Bin Lee, Jae-Young Lee, So-Yeon Kim, Yung-Choon Yoo, Jae-Hee Ahn, Eun-Hye Hong, Chae-Won Kim, Su Min Kim, Hye Hyun Yoo, Joo Young Huh, Hyun-Jeong Ko, and Jong-Hwan Park.
• Laboratory Animal Medicine, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 61186, Republic of Korea; Nodcure, INC., 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
• Nutrition. 2024 Dec 1; 128: 112565112565.

ObjectivesThis study investigated the therapeutic potential of Lactobacillus plantarum NCHBL-004 (NCHBL-004) in the treatment of obesity and associated metabolic disorders.MethodsMice were fed either a normal diet (ND) or a high-fat diet (HFD) with oral administration of NCHBL-004. After euthanasia, blood, liver and adipose tissue were collected. Furthermore, the microbiome and short-chain fatty acids (SCFAs) were analyzed from feces.ResultsOral administration of live NCHBL-004 to mice fed a HFD resulted in notable reductions in weight gain, improvements in glucose metabolism, and maintenance of balanced lipid levels. A comparative analysis with other Lactobacillus strains highlighted the superior efficacy of NCHBL-004. Moreover, heat-killed NCHBL-004 demonstrated beneficial effects similar to those of live NCHBL-004. Additionally, administration of live NCHBL-004 induced glucagon-like peptide 1 (GLP-1) production and increased the levels of short-chain fatty acids (SCFAs), including acetate and propionate, in feces, positively influencing liver lipid metabolism and mitigating inflammation. Consistent with this, analysis of the gut microbiome following NCHBL-004 administration showed increases in SCFA-producing microbes with increased proportions of Lactobacillus spp. and a significant increase in the proportion of microbes capable of promoting GLP-1 secretion.ConclusionsThese findings underscore the potential of both live and inactivated NCHBL-004 as potential therapeutic approaches to managing obesity and metabolic disorders, suggesting avenues for further investigation and clinical applications.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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