• Arch Med Sci · Jan 2024

    Sanguiin inhibits cerebral hemorrhage in rats by protecting the blood-brain barrier.

    • Liguo Zhang, Jing Li, Yisong Zhang, and Hengzhu Zhang.
    • Department of Neurosurgery, The Dalian School of Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China.
    • Arch Med Sci. 2024 Jan 1; 20 (4): 134513481345-1348.

    IntroductionThe aim of the study was to observe the effect of Sanguiin on cerebral edema and behavior in a rat cerebral hemorrhage model.MethodsA rat collagenase-induced cerebral hemorrhage model was established to detect the effects of drugs on brain edema.ResultsThrough magnetic resonance imaging (MRI) analysis and brain weight content (BWC) determination, it was found that Sanguiin could significantly reduce the brain swelling index and BWC of the affected hemisphere after cerebral hemorrhage.ConclusionsSanguiin can significantly improve the neurological deficits in rats with cerebral hemorrhage, and down-regulate the expression of MMP-9 after cerebral hemorrhage, suggesting that Sanguiin has a certain protective effect on the blood-brain barrier after cerebral hemorrhage.Copyright: © 2024 Termedia & Banach.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…