• Tohoku J. Exp. Med. · Sep 1983

    Comparative Study

    Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.

    • N Morisaki, N Matsuoka, Y Saito, and A Kumagai.
    • Tohoku J. Exp. Med. 1983 Sep 1; 141 (1): 333933-9.

    AbstractThe mechanism of the activating effect of pantethine [D-bis-(N-pantothenyl-beta-aminoethyl)disulfide] on fatty acid oxidation was investigated in rat liver mitochondria. Pantethine, pantetheine and 4'-phosphopantetheine activated three steps of fatty acid oxidation, i.e., acyl-CoA synthetase, carnitine, acyltransferase and intramitochondrial oxidation, to various extents. Although their effects may have been partly due to CoASH derived from them, they also had specific effects.

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