• Saudi Med J · Feb 2025

    Association between factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) genetic polymorphisms and recurrent spontaneous miscarriage in Saudi women.

    • Aaishah M Kaabi, Afrah F Alkhuriji, Zeneb A Babay, Ibrahim A Barakat, Abdullah M Kaabi, and Reem M Kaabi.
    • From the Department of Zoology (Aaishah Kaabi, Al-Khuriji), College of Science; from the Department of Obstetrics and Gynecology (Babay)King Saud University; from the Central Military Laboratory & Blood Bank (Abdullah Kaabi), Prince Sultan Military Medical City, Riyadh; and from the Department of Laboratory and Blood Bank (Reem Kaabi), Al-Bukayriyah General Hospital, Qassim, Kingdom Saudi Arabia; and from the Cell Biology Department (Barakat), National Research Center, Giza, Egypt.
    • Saudi Med J. 2025 Feb 1; 46 (2): 150156150-156.

    ObjectivesTo identify genetic polymorphisms in factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) in Saudi women with recurrent spontaneous miscarriage (RSM). Furthermore, to compare the levels of clotting factors in the blood of patients and healthy controls.MethodsThe current study was conducted at the King Khalid University Hospital in Riyadh, Saudi Arabia, from September 2022 to June 2023. The study involved 100 Saudi women, 50 pregnant and 50 non-pregnant individuals, who experienced RSM. Furthermore, 100 healthy Saudi women, including 50 pregnant and 50 non-pregnant individuals, were also included as controls. TaqMan genotyping assays were used to determine single nucleotide polymorphisms in the promoter regions of the factor I and XI genes.ResultsA significant correlation was found between the Factor I fibrinogen genotype (rs6050 C/T) and RSM in non-pregnant Saudi women. However, no significant correlation was observed between the Factor XI polymorphism (rs4253417 C/T) and RSM.ConclusionWe demonstrated a significant correlation between genetic polymorphisms in factor I fibrinogen in certain genes studied and RSM. This association could be attributed to changes in fibrinogen levels, which impact the coagulation process and lead to an increase in thrombotic events, which are recognized as risk factors for miscarriage. Notably, variations in the other genes examined did not exhibit any association with the risk of RSM.Copyright: © Saudi Medical Journal.

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