• Moslem Shakeri, Mohammad Reza Boustani, Neda Pak, Farid Panahi, Firouz Salehpour, Iraj Lotfinia, Ali Meshkini, Shadi Daghighi, Payman vahedi, Mehdi Khani, and Dariush Taghiloo.
• Department of Neurosurgery, Imam Reza Teaching Hospital, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
• Clin Neurol Neurosurg. 2013 Oct 1;115(10):2019-22.

ObjectiveSevere traumatic brain injury (TBI) has a major role in mortality rate among the other types of trauma. The aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with acute severe TBI.MethodsA total of 76 patients who had arrived within 8h of injury with a Glasgow Coma Score≤8 were enrolled in the study. In a randomized style 38 received progesterone (1mg/kg per 12h for 5 days) and 38 did not.ResultsThere was a better recovery rate and GOS score for the patients who were given progesterone than for those in the control group in a 3-months follow-up period (50% vs. 21%); subgroup analysis showed a significant difference in the percentage of favorable outcome between the two groups with GCS of 5-8 (p=0.03).ConclusionThe use of progesterone may significantly improve neurologic outcome of patients suffering severe TBI up to 3 months after injury, especially those with 5≤GCS≤8, providing a potential benefit to the treatment of acute severe TBI patients. Considering this drug had no significant side effects, so progesterone could be used in patients with severe TBI as a neuro-protective drug.Copyright © 2013 Elsevier B.V. All rights reserved.

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