-
Review Meta Analysis
Nebulized morphine for relief of dyspnea due to chronic lung disease.
- Sherrill J Brown, Samantha F Eichner, and Jennifer R Jones.
- College of Health Professions and Biomedical Sciences, Skaggs School of Pharmacy, University of Montana, Missoula, MT 59812-1522, USA. sherrill.brown@umontana.edu
- Ann Pharmacother. 2005 Jun 1;39(6):1088-92.
ObjectiveTo evaluate the efficacy and safety of nebulized morphine for the management of dyspnea in chronic pulmonary diseases.Data SourcesMEDLINE (1966-May 2004), EMBASE (1980-May 2004), and International Pharmaceutical Abstracts (1970-May 2004) searches were performed. Key search terms included morphine, dyspnea, and inhalation.Data SynthesisNine studies have evaluated the efficacy of nebulized morphine in relieving dyspnea. Three trials had positive results, but the rest failed to show improvement after treatment with doses ranging from 1 to 40 mg nebulized morphine. The small number of subjects, variety of disease states, and different outcome measures limit interpretation of the studies.ConclusionsResults from several small studies do not support the use of nebulized morphine for treatment of dyspnea; however, several positive case reports have been published.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..