The Annals of pharmacotherapy
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Review Meta Analysis
Nebulized morphine for relief of dyspnea due to chronic lung disease.
To evaluate the efficacy and safety of nebulized morphine for the management of dyspnea in chronic pulmonary diseases. ⋯ Results from several small studies do not support the use of nebulized morphine for treatment of dyspnea; however, several positive case reports have been published.
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To report a case of sulfhemoglobinemia in a patient receiving phenazopyridine for a urinary tract infection. ⋯ This case of sulfhemoglobinemia, which occurred after the patient took phenazopyridine, is considered a probable adverse event according to the Naranjo probability scale.
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Letter Case Reports
Use of gabapentin for rest pain in chronic critical limb ischemia.
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Randomized Controlled Trial Comparative Study
Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity.
Eye examinations for retinopathy of prematurity (ROP) are painful to the neonate. The use of topical anesthetic for eye examinations to evaluate ROP is routine in our neonatal intensive care unit (NICU), but does not completely suppress painful responses. Sweet solutions have been shown to reduce procedural pain in newborns. ⋯ Oral sucrose may reduce the immediate pain response in premature infants undergoing eye examination for ROP.
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Tramadol is a unique analgesic that has been associated with seizures on overdose. ⋯ Tramadol overdoses frequently cause CNS depression, nausea/vomiting, tachycardia, and seizures. Symptoms generally resolve within 24 hours. Accidental ingestions in children were well tolerated, primarily causing sedation.