• J D Swenson, R M Hullander, and D Leivers.
• Department of Anesthesiology, University of Utah Medical Center, Salt Lake City 84132, USA.
• J Clin Anesth. 1995 Sep 1;7(6):477-80.

Study ObjectiveTo determine the effect of intrathecal sufentanil on volatile anesthetic requirements during lower abdominal surgery.DesignRandomized, double-blind study.SettingMilitary tertiary care hospital.Patients15 female patients, ASA status I and II, undergoing elective lower abdominal surgery.InterventionsAfter induction of anesthesia, each patient had a lumbar puncture performed with a 24-gauge Sprotte needle through a Tuohy needle positioned in the epidural space to receive either intrathecal sufentanil 10 micrograms or intrathecal normal saline (control). An epidural catheter was then placed for use in postoperative analgesia. Anesthesia was maintained in all patients with isoflurane, air, and oxygen. Gas flows were constant and the isoflurane concentration was adjusted at 5-minute intervals to maintain systolic blood pressure within 20% of preoperative baseline.Measurements And Main ResultsThe mean end-tidal isoflurane concentration during the first hour of surgery was significantly lower in the sufentanil group (0.74 +/- 0.02%) compared with the control group (1.05 +/- 0.03%) (p = 0.006), an overall reduction of 28% in the isoflurane requirement.ConclusionPrior administration of intrathecal sufentanil significantly decreases the isoflurane requirement in surgical patients, in addition to its previously demonstrated rapid onset and receptor efficacy.

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