• Tal Tirosh-Wagner, Tzipi Strauss, Marina Rubinshtein, Ilia Tamarin, David Mishaly, Gideon Paret, and Gili Kenet.
• Department of Pediatrics of the Edmond and Lily Safra Children's Hospital, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
• Pediatr Blood Cancer. 2011 May 1;56(5):794-8.

BackgroundExcessive hemorrhage is a major complication after cardiac surgery requiring cardiopulmonary bypass (CPB). The aim of this study was to define the potential role of the cone and platelet analyzer (CPA) and the rotating thromboelastogram (ROTEM) point of care tests in children undergoing CPB.ProcedureWe prospectively studied 15 pediatric patients aged 1 month to 10 years. Blood count, blood coagulation tests (prothrombin time [PT], activated partial thromboplastin time, fibrinogen, thrombin time), CPA and ROTEM parameters were measured before and after CPB. Demographic and surgical data were recorded as were those on perioperative blood loss and blood product transfusion.ResultsLow body weight, longer duration on CPB and lower core body temperature were associated with an increased bleeding risk. The ROTEM test showed a significant prolongation of clotting time and decreased maximal clot firmness (MCF) postoperatively in children with increased bleeding. The coagulation parameters associated with increased bleeding were: prolonged PT, lower fibrinogen levels, prior to surgery, and lower MCF after surgery. CPA test findings were not associated with postoperative bleeding in our patients.ConclusionsCPA did not serve as a prognostic tool for predicting bleeding risk in children undergoing CPB. The change in ROTEM's post-CPB results associated with bleeding tendency, and they may predict for poorer clot formation and stability.Copyright © 2010 Wiley-Liss, Inc.

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