• Handb Clin Neurol · Jan 2013

    Review

    Deep brain stimulation for cognitive disorders.

    • Adrian W Laxton, Nir Lipsman, and Andres M Lozano.
    • Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
    • Handb Clin Neurol. 2013 Jan 1;116:307-11.

    AbstractDisorders of cognition are a major societal burden. As the population grows and ages, these conditions demand urgent attention, as healthcare resources stretch to accommodate the growing number of patients. Although much is known about the neurobiology of dementia and Alzheimer's disease (AD), few treatments are available to arrest or slow down the illness. By targeting specific structures within known circuits, deep brain stimulation (DBS) can have effects across memory and cognitive networks, and is therefore a potentially promising avenue for novel dementia treatments. This chapter reviews the literature on DBS for AD and dementia associated with Parkinson's disease, and highlight some of the neuroanatomical targets that offer the most promise in modulating the underlying pathological activity in brain circuitry.© 2013 Elsevier B.V. All rights reserved.

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