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- David L Gillespie, Jeannette R Flynn, Brian T Ragel, Maria Arce-Larreta, David A Kelly, Sheryl R Tripp, and Randy L Jensen.
- Department of Neurosurgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
- Methods Mol. Biol. 2009 Jan 1;487:283-301.
AbstractHigher-grade gliomas are distinguished by increased vascular endothelial cell proliferation and peritumoral edema. These are thought to be instigated by vascular endothelial growth factor, which in turn is regulated by cellular oxygen tension. Hypoxia inducible factor-1alpha (HIF-1alpha) is a main responder to intracellular hypoxia and is overexpressed in many human cancers, including gliomas. Here we present methods for investigating the role of HIF-1alpha in glioma growth in vivo and in vitro using RNA interference in U251, U87, and U373 glioma cells.
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