• C Raina MacIntyre, Quanyi Wang, Bayzidur Rahman, Holly Seale, Iman Ridda, Zhanhai Gao, Peng Yang, Weixian Shi, Xinghuo Pang, Yi Zhang, Aye Moa, and Dominic E Dwyer.
• School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia; National Centre for Immunization Research and Surveillance, The Children's Hospital at Westmead, Sydney, Australia.
• Prev Med. 2014 May 1; 62: 1-7.

ObjectiveWe compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs).MethodsA cluster randomized clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR).ResultsThe rate of bacterial colonization was 2.8% in the N95 group (p=0.02), 5.3% among medical mask users (p<0.01) and 7.5% among the controls (p=0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm.ConclusionsN95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers.Copyright © 2014. Published by Elsevier Inc.

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