• Kaundinya Gopinath, Wendy Ringe, Aman Goyal, Kirstine Carter, Hubert R Dinse, Robert Haley, and Richard Briggs.
• Department of Radiology, Division of Neuroradiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8896, USA. kaundinya.gopinath@utsouthwestern.edu
• Neuroimage. 2011 Jan 1;54(1):380-8.

AbstractResting state fluctuations in blood oxygenation level dependent functional connectivity magnetic resonance imaging (BOLD fcMRI) time-series have been increasingly employed to study functional connectivity networks in healthy and diseased brain. FcMRI studies have been conducted under a number of different conditions, including resting eyes open, visual fixation and finger tapping. BOLD fcMRI networks are believed to reflect both anatomically constrained spontaneous fluctuations and state-dependent activity. In this study, state-dependence of functional connectivity to dorsal and ventral striatum was assessed with fcMRI during an eyes open resting state condition (REST) and during continuous 3 Hz transcutaneous electrical nerve stimulation (TENS), with the a priori hypotheses: (1) dorsal striatum connectivity with sensorimotor/attention networks will be stronger during TENS compared to REST, (2) ventral striatum connectivity with limbic system emotion-processing network will be weaker during TENS compared to REST and (3) ventral striatum connectivity with sensorimotor/attention networks will be stronger during TENS compared to REST. These hypotheses were confirmed by the results obtained, indicating that resting state BOLD fMRI networks reflect, in substantial measure, state-dependent activity.Copyright © 2010 Elsevier Inc. All rights reserved.

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