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Clin Neurol Neurosurg · Apr 2003
Clinical TrialIs mannitol safe for patients with intracerebral hemorrhages? Renal considerations.
- Tomasz Dziedzic, Andrzej Szczudlik, Aleksandra Klimkowicz, Teresa M Rog, and Agnieszka Slowik.
- Department of Neurology, Stroke Unit, Jagiellonian University, 31-503 Kraków, ul. Botaniczna 3, Poland. dziedzictom@mediclub.pl
- Clin Neurol Neurosurg. 2003 Apr 1;105(2):87-9.
ObjectivesMannitol, a drug widely used to decrease intracranial pressure, can cause renal failure. The goal of this study is to determine the renal safety of mannitol therapy in patients with intraparenchymal hemorrhages.Material And Methods51 patients with intracerebral hemorrhages were treated with mannitol according to guideline of American Heart Association. Serum urea and creatinine levels were measured before mannitol administration and on the 2nd, 5th and 14th day.ResultsTransient elevation of urea and creatinine concentration was noticed, however, none of patients developed anuria or oliguria.ConclusionsOur study points out safety of mannitol therapy under control of osmolality, although control of urea and creatinine concentrations in special group of patients (persons with history of renal failure or diabetes) should be considered.
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