• J C De Mey, G Rolly, and N Den Blauwen.
• Department of Anesthesiology, University Hospital, Ghent, Belgium.
• J Clin Anesth. 1995 Sep 1; 7 (6): 453-6.

Study ObjectiveTo determine the influence of aging on the efficacy and safety of doxacurium.DesignOpen, randomized, phase III study.SettingInpatient ophthalmic surgery clinic at a university medical center.Patients30 elderly patients (65 years or older) compared with a control group of 30 younger patients (18 to 64 years).InterventionsAn elective ophthalmological surgical intervention of more than 2 hours' expected duration with general anesthesia with isoflurane.Measurements And Main ResultsNeuromuscular function after a bolus dose of doxacurium was monitored electromyographically. No significant difference was observed in maximum block achieved or onset time. Clinical duration of neuromuscular block was similar in both groups. Hemodynamic changes were clinically unimportant.ConclusionThe use of doxacurium in elderly patients is possible with no need for dose adjustment. Doxacurium might be a good choice for patients with cardiac disease who are scheduled for long surgical procedures.

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