• Pediatric blood & cancer · Sep 2015

    Review

    Early insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature.

    • Amanda M Brandow, Rebecca A Farley, and Julie A Panepinto.
    • Section of Pediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
    • Pediatr Blood Cancer. 2015 Sep 1; 62 (9): 1501-11.

    AbstractNovel insights into the neurobiology of sickle cell disease (SCD) pain have recently been discovered. We systematically reviewed the literature focusing on original research that examined the biology of pain in SCD and/or addressed assessment or treatment of neuropathic pain in SCD. This review of 15 articles that met inclusion criteria provides epidemiological, basic, and clinical data that support central and/or peripheral nervous system abnormalities likely contribute to sickle cell pain. Continued basic and clinical investigation into pain neurobiology is imperative to translate these discoveries into novel ways to assess and treat neuropathic pain and decrease patient suffering.© 2015 Wiley Periodicals, Inc.

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