Pediatric blood & cancer
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Pediatric blood & cancer · Sep 2015
Value of surgical resection in children with high-risk neuroblastoma.
The value of gross total resection (GTR) for children with high-risk neuroblastoma (NB) is controversial. We hypothesized that patients undergoing GTR would demonstrate improved overall survival (OS) compared those having
90% resection is associated with improved OS compared to less than 90% resection. -
Pediatric blood & cancer · Sep 2015
ReviewEarly insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature.
Novel insights into the neurobiology of sickle cell disease (SCD) pain have recently been discovered. We systematically reviewed the literature focusing on original research that examined the biology of pain in SCD and/or addressed assessment or treatment of neuropathic pain in SCD. This review of 15 articles that met inclusion criteria provides epidemiological, basic, and clinical data that support central and/or peripheral nervous system abnormalities likely contribute to sickle cell pain. Continued basic and clinical investigation into pain neurobiology is imperative to translate these discoveries into novel ways to assess and treat neuropathic pain and decrease patient suffering.