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Randomized Controlled Trial Clinical Trial
Epidural scopolamine administration in preventing nausea after epidural morphine.
- R Moscovici, G Prego, M Schwartz, and O Steinfeld.
- Department of Anesthesiology, Emek Medical Center, Afula, Israel.
- J Clin Anesth. 1995 Sep 1; 7 (6): 474-6.
Study ObjectiveTo determine the effectiveness of epidural scopolamine in preventing nausea and vomiting in patients receiving epidural morphine.DesignRandomized, double-blind study.SettingInpatient surgery clinic at a regional general hospital.Patients50 patients undergoing major abdominal and lower limb surgery.InterventionsMorphine alone 2.5 to 4 mg was administered via epidural catheter to one group, while the other group received morphine plus scopolamine 0.25 mg via epidural catheter.Measurements And Main ResultsOccurrence of nausea and vomiting was recorded during the first postoperative day. Compared with the morphine alone group, the incidence of nausea and vomiting was significantly lower in the morphine plus scopolamine group without difference in the adequacy of analgesia.ConclusionEpidural scopolamine can be used as an adjunct to epidural morphine in effectively reducing the incidence of postoperative nausea and vomiting.
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