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Vet. Clin. North Am. Food Anim. Pract. · Jul 2014
ReviewAcid-base assessment: when and how to apply the Henderson-Hasselbalch equation and strong ion difference theory.
- Peter D Constable.
- College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA. Electronic address: constabl@illinois.edu.
- Vet. Clin. North Am. Food Anim. Pract. 2014 Jul 1; 30 (2): 295-316, v.
AbstractThe Henderson-Hasselbalch equation is probably the most famous equation in biology but is more descriptive than mechanistic. The traditional approach to acid-base assessment using the Henderson-Hasselbalch equation provides a clinically useful and accurate method when plasma protein concentrations are within the reference range. The simplified strong ion approach is a mechanistic acid-base model that can provide new insight into complicated acid-base disturbances. The simplified strong ion approach should be used to evaluate acid-base balance whenever plasma protein concentrations are abnormal.Copyright © 2014 Elsevier Inc. All rights reserved.
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