• Neuroscience · Oct 2016

    Decreased adult neurogenesis in hibernating Syrian hamster.

    • Gonzalo León-Espinosa, Esther García, Ulises Gómez-Pinedo, Félix Hernández, Javier DeFelipe, and Jesús Ávila.
    • Instituto Cajal, CSIC, Madrid, Spain; Laboratorio Cajal de Circuitos Corticales (CTB), Universidad Politécnica de Madrid, Madrid, Spain; Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain. Electronic address: gleon@cajal.csic.es.
    • Neuroscience. 2016 Oct 1; 333: 181-92.

    AbstractGeneration of new neurons from adult neural stem cells occurs in the dentate gyrus (DG) of the hippocampus and the lateral walls of the lateral ventricles. In this article, we study the neurogenesis that takes place during the hibernation of the Syrian hamster (Mesocricetus auratus). Using a variety of standard neurogenesis markers and 5-bromo-2-deoxyuridine (BrdU) incorporation, we describe a preferential decrease in the proliferation of newborn neurons in the subventricular zone (SVZ) of the hibernating hamsters (torpor) rather than in the hippocampus. Furthermore, we demonstrate that the proliferative capacity is recovered after 3-4days of torpor when arousal is triggered under natural conditions (i.e., not artificially provoked). In addition, we show that tau3R, a tau isoform with three microtubule-binding domains, is a suitable marker to study neurogenesis both in the SVZ and subgranular zone (SGZ) of the Syrian hamster brain.Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

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