• Tilo Niemann, Lucie Colas, Hans W Roser, Teresa Santangelo, Jean Baptiste Faivre, Jaques Remy, Martine Remy-Jardin, and Jens Bremerich.
• Department of Radiology, Cantonal Hospital Baden, Im Ergel 1, 5400, Baden, Switzerland, tilo.niemann@ksb.ch.
• Pediatr Radiol. 2015 Mar 1; 45 (3): 329-36.

BackgroundThe increasing absolute number of paediatric CT scans raises concern about the safety and efficacy and the effects of consecutive diagnostic ionising radiation.ObjectiveTo demonstrate a method to evaluate the lifetime attributable risk of cancer incidence/mortality due to a single low-dose helical chest CT in a two-year patient cohort.Materials And MethodsA two-year cohort of 522 paediatric helical chest CT scans acquired using a dedicated low-dose protocol were analysed retrospectively. Patient-specific estimations of radiation doses were modelled using three different mathematical phantoms. Per-organ attributable cancer risk was then estimated using epidemiological models. Additional comparison was provided for naturally occurring risks.ResultsTotal lifetime attributable risk of cancer incidence remains low for all age and sex categories, being highest in female neonates (0.34%). Summation of all cancer sites analysed raised the relative lifetime attributable risk of organ cancer incidence up to 3.6% in female neonates and 2.1% in male neonates.ConclusionUsing dedicated scan protocols, total lifetime attributable risk of cancer incidence and mortality for chest CT is estimated low for paediatric chest CT, being highest for female neonates.

22 keywords...

hide…