• Neuroscience · Sep 2018

    Intrastriatal chromospheres transplant reduces nociception in hemiparkinsonian rats.

    • Alejandra Gómez-Paz, René Drucker-Colín, Diana Milán-Aldaco, Marcela Palomero-Rivero, and Mónica Ambriz-Tututi.
    • Departamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico.
    • Neuroscience. 2018 Sep 1; 387: 123-134.

    AbstractThe present study evaluates the possible antinociceptive effect of chromosphere transplants in rats injected with 6-hydroxydopamine (6-OHDA), a model of Parkinson's disease. Male adult Wistar rats received 40μg/0.5μl of 6-OHDA or 0.5μl of vehicle into the left substantia nigra (SNc). Rats were evaluated for mechanical allodynia, cold allodynia, thermal hyperalgesia and formalin. Rats with altered nociceptive threshold were transplanted with chromospheres. After transplant, rats were evaluated every week. Our results confirm that 6-OHDA injection into rat's SNc reduces mechanical, thermal, and chemical thresholds. Interestingly, chromospheres' transplant reverted 6-OHDA-induced allodynia and hyperalgesia. The antinociceptive effect induced by chromospheres was dopamine D2- and opioid-receptor dependent since sulpiride or naltrexone reverted its effect.Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

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