• Y Lu, F Zhong, X Wang, H Li, Z Zhu, X Kong, J Zhao, and Q Wu.
• Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi province 710061, China; Department of Physiology, Heze Medical College, Heze, Shandong Province, China. Electronic address: luyong20306@163.com.
• Neuroscience. 2015 Jan 22;284:374-80.

ObjectiveThe effects of motilin on voltage-dependent K+ currents in hippocampal neurons with the addition of L-arginine (L-AA), D-arginine (D-AA) and N-nitro-L-arginine methyl ester (L-NAME) were investigated in this study.MethodsMice (1-3 days old) were randomly assigned to different groups according to the addition of motilin, L-AA, D-AA, and L-NAME. The K+ current signals were detected by the whole-cell patch-clamp technique.ResultsCompared with the control group, the transient outward voltage-dependent K+ current was significantly inhibited by motilin added with L-AA. In contrast, the addition of motilin and L-NAME significantly increased the K+ current, while no significant change was detected by the addition of motilin accompanied with D-AA.ConclusionThe inhibiting effects of motilin on the voltage-dependent K+ current in hippocampal neurons indicate that motilin acts as a regulatory factor for the nitric oxide pathway.Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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