• Neuroscience · Jan 2015

    Spinal cord injury induces a long-lasting upregulation of interleukin-1β in astrocytes around the central canal.

    • B Paniagua-Torija, A Arevalo-Martin, E Molina-Holgado, F Molina-Holgado, and D Garcia-Ovejero.
    • Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Paraplejicos (SESCAM), 45071 Toledo, Spain. Electronic address: bpaniagua@sescam.jccm.es.
    • Neuroscience. 2015 Jan 22;284:283-9.

    AbstractUnder inflammatory conditions, interleukin-1β (IL-1β) modulates neural stem cells at neurogenic niches. Here we show that spinal cord injury in rats increases IL-1β expression in astrocytes located around the spinal cord ependyma, a region that also holds a neurogenic potential. IL-1β increases from day 1 after lesion, reaches maximal levels between days 3 and 7, and declines from 14 days to low levels after 28 days. At the time of maximal expression, periependymal upregulation of IL-1β extends beyond 5 mm from the epicenter of the lesion both rostral and caudally. Since IL-1β controls proliferation and cell fate of neural stem/precursor cells, its modulation in periependymal astrocytes might create an appropriate environment for cell replacement after injury.Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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