• T Hashimoto, K Kitajo, T Kajihara, K Ueno, C Suzuki, T Asamizuya, and A Iriki.
• Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City 351-0198, Japan; Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryocho, Aobaku, Sendai 980-8575, Japan. Electronic address: thashimoto@idac.tohoku.ac.jp.
• Neuroscience. 2015 Mar 19;289:1-8.

AbstractAlthough the neural correlates that underlie abdominal pain have been investigated, so-called brain processes involved in modulating "gut feelings" remain unclear. In the current study, we used electrointestinography (EIG) to measure intestinal activity of healthy humans at rest. EIG measured myoelectrical activity of intestinal smooth muscles from the abdominal surface and was simultaneously conducted along with brain activity measurement using functional magnetic resonance imaging (fMRI). Correlations between the frequency powers of EIG and fMRI signals during 30min of rest were then examined to elucidate gut-brain interactions. Neural activity correlating with 0.14- to 0.21-Hz EIG (suggested to reflect intestinal activity) was observed in the right anterior and middle insula. Moreover, this EIG frequency band correlated with anxiety scores along with resting-state functional connectivity between the insula and dorsal anterior cingulate cortex. These findings suggest that the insular cortex could be the core region involved in central visceral processes associated with subjective feelings.Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

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