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- Z Yao, Z Wang, N Yuan, Z Liang, and Y Zhou.
- CAS Key Laboratory of Brain Function and Diseases, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
- Neuroscience. 2015 Mar 19;289:358-66.
AbstractTo investigate the effect of senescence on signal transmission, we have compared the visual response latency and spontaneous activity of cells in the lateral geniculate nucleus (LGN), area 17, area 18 and posteromedial lateral suprasylvian area (PMLS) of young and old cats. We found that LGN cells in old cats exhibit largely normal visual response latency. In contrast, all the other three areas exhibited significant aging-related delays in the visual response latency. On average, PMLS showed most pronounced delays among these three areas. Area 18 slowed more than area 17, but this was not significant. The degradation of signal timing in the visual cortex might provide insight into neuronal response mechanism underlying perception slowing during aging.Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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