• Nutrition · Feb 2020

    Fish oil-rich lipid emulsion modulates neuroinflammation and prevents long-term cognitive dysfunction after sepsis.

    • Amanda Della Giustina, Mariana Pereira Goldim, Lucinéia Gainski Danielski, Drielly Florentino, Leandro Garbossa, Larissa Joaquim, Aloir Neri Oliveira Junior, Khiany Mathias, Maria Eduarda Fileti, Graciela Freitas Zarbato, Naiana da Rosa, Laurentino Ana Olívia Martins AOM Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, University of South Santa Catar, Jucélia Jeremias Fortunato, Juliete Palandi, Bruna Hoffmann de Oliveira, Daniel Fernandes Martins, Franciane Bonbinski, Tatiani Bellettini-Santos, Michele Garcez, Josiane Budni, Tatiana Barichello, and Fabricia Petronilho.
    • Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil.
    • Nutrition. 2020 Feb 1; 70: 110417.

    ObjectivesSepsis is a severe organic dysfunction caused by an infection that affects the normal regulation of several organ systems, including the central nervous system. Inflammation and oxidative stress play crucial roles in the development of brain dysfunction in sepsis. The aim of this study was to determine the effect of a fish oil (FO)-55-enriched lipid emulsion as an important anti-inflammatory compound on brain dysfunction in septic rats.MethodsWistar rats were subjected to sepsis by cecal ligation and perforation (CLP) or sham (control) and treated orally with FO (600 µL/kg after CLP) or vehicle (saline; sal). Animals were divided into sham+sal, sham+FO, CLP+sal and CLP+FO groups. At 24 h and 10 d after surgery, the hippocampus, prefrontal cortex, and total cortex were obtained and assayed for levels of interleukin (IL)-1β and IL-10, blood-brain barrier permeability, nitrite/nitrate concentration, myeloperoxidase activity, thiobarbituric acid reactive species formation, protein carbonyls, superoxide dismutase and catalase activity, and brain-derived neurotrophic factor levels. Behavioral tasks were performed 10 d after surgery.ResultsFO reduced BBB permeability in the prefrontal cortex and total cortex of septic rats, decreased IL-1β levels and protein carbonylation in all brain structures, and diminished myeloperoxidase activity in the hippocampus and prefrontal cortex. FO enhanced brain-derived neurotrophic factor levels in the hippocampus and prefrontal cortex and prevented cognitive impairment.ConclusionsFO diminishes the negative effect of polymicrobial sepsis in the rat brain by reducing inflammatory and oxidative stress markers.Copyright © 2018 Elsevier Inc. All rights reserved.

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