• Methods Mol. Biol. · Jan 2017

    MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role.

    • Lihua Zhang, Daniel Miller, Qiuping Yang, and Bin Wu.
    • Department of Geriatrics, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650031, China.
    • Methods Mol. Biol. 2017 Jan 1; 1617: 241-260.

    AbstractEven though it is a pandemic health problem worldwide, the pathogenesis of obesity is poorly understood. Recently, emerging studies verified that microRNAs (miRNAs) are involved in complicated metabolic processes including adipocyte differentiation, fat cell formation (adipogenesis), obesity-related insulin resistance and inflammation. Many regulatory networks have been identified in murine adipose tissue, but those in human adipose tissue are not as well known. In addition, miRNAs have been detected in circulation, and thus may be usable as diagnostic indicators. MiRNAs may play an important part in regulating metabolic functions in adipose tissues and, by extension, obesity and its associated disorders. Consequently, they may be potential candidates for therapeutic targets and biomarkers.

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