• Di Li, Yongqing Tong, and Yan Li.
• Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: ld_director@qq.com.
• Nutrition. 2020 Mar 1; 71: 110602.

ObjectivesThe aim of this study was to review the association of dietary intake of oleic and linoleic acids (OA and LA, respectively) with depressive symptoms in perimenopausal women.MethodsThis cross-sectional study used data from the Study of Women's Health Across the Nation (SWAN). Linear and logistic regressions and restricted cubic spline models were performed to examine the association of intake of OA and LA with depression.ResultsWe included 2793 women 42 to 52 y of age in the present study. Intake of the two acids was positively associated with the Center for Epidemiologic Studies Depression Scale (CES-D) scores in unadjusted and age-, race/ethnicity-, total family income- and education-adjusted linear regression model. The fully adjusted regression coefficients were β = 0.089 and β = 0.145 for oleic and linoleic acid intake, respectively. OA and LA intake was positively associated with depressive symptoms (CES-D score ≥16) in unadjusted and age-, race/ethnicity-, total family income- and education-adjusted logistic regression model. The fully adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of depressive symptoms were 1.994 (1.298-3.063) and 1.592 (1.047-2.421) for the highest versus lowest quartile of intake of OA and LA, respectively.ConclusionIntake of OA and LA may be positively associated with depressive symptoms in perimenopausal women.Copyright © 2019 Elsevier Inc. All rights reserved.

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