• Juan Miguel Martínez-Galiano, Carmen Amezcua-Prieto, Naomi Cano-Ibañez, Rocío Olmedo-Requena, Jose Juan Jiménez-Moleón, Aurora Bueno-Cavanillas, and Miguel Delgado-Rodríguez.
• Department of Nursing, University of Jaen, Jaen, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, Madrid, Spain. Electronic address: juanmimartinezg@hotmail.com.
• Nutrition. 2020 Apr 1; 72: 110665.

ObjectiveThe aim of this study was to assess whether diet variables can neutralize the risk produced by three well-known risk factors for being small for gestational age: smoking, body mass index (BMI) ˂20 kg/m2, and having a previous preterm/low birth weight (LBW) newborn.MethodsA matched case control study was conducted (518 cases and 518 controls of pregnant women) in Spain. We collected data on demographic characteristics, socioeconomic status, toxic habits, and diet. Dietary intake during pregnancy was assessed using a validated food frequency questionnaire, categorized into quintiles. Adjusted odds ratios (aORs) and their 95% confidence intervals (CI) were estimated by conditional regression logistic models.ResultsWomen who smoked during pregnancy had a 78% increased risk for having an SGA newborn (aOR, 1.78; 95% CI, 1.28-2.74). Lean women (BMI ˂ 20 kg/m2 before pregnancy) augmented the risk 139% (aOR, 2.39; 95% CI, 1.68-3.40), and those with a previous SGA-LBW an increase of 160% (aOR, 2.60; 95% CI, 1.53-4.37). Smoking in women with a fruit intake of ≥421 g/d was not associated with a higher risk for SGA versus non-smoking women with the same fruit intake (aOR, 0.98; 95% CI, 0.41-2.33). A BMI <20 kg/m2 with an intake of ≥33 g/d of legumes did not increase the risk for SGA versus women with a BMI ≥20 kg/m2 with the same legume intake (aOR, 1.35; 95% CI, 0.54-3.37). Diet did not modify the risk by having a previous SGA-LBW newborn.ConclusionsSmoking and leanness increased the SGA risk; nevertheless foods such as fruit, fish, and legumes, as well as intake of vitamins D and B3 and ω-3 marine fatty acids, may "at" least partially counteract this increase.Copyright © 2019 Elsevier Inc. All rights reserved.

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