• Nutrition · May 2020

    Review

    Manipulation of microbiota with probiotics as an alternative for treatment of hepatic encephalopathy.

    • Renata Rivera-Flores, Segundo Morán-Villota, Luisa Cervantes-Barragán, Constantino López-Macias, and Misael Uribe.
    • Laboratorio de Investigación en Gastro-Hepatología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    • Nutrition. 2020 May 1; 73: 110693.

    AbstractHepatic encephalopathy is a cerebral alteration mainly caused by hepatic insufficiency or portosystemic shunt. It ranges from minimal neurologic manifestations to coma in its overt stage. The multifactorial pathophysiology of hepatic encephalopathy has rendered numerous treatment alternatives, among which the modification of dysbiosis and hyperammonemia are currently considered to be effective, not only clinically, but also regarding cost. Recent work has developed knowledge of probiotics in different clinical settings including the relationship of the gut microenvironment to liver cirrhosis. The aim of this review was to analyze the results of clinical trials on the effect of different probiotics on hepatic encephalopathy.Copyright © 2019. Published by Elsevier Inc.

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