• Pricila Romão Marcondes Ávila, Monique Michels, Francieli Vuolo, Rafaela Bilésimo, Henrique Burger, Maria Vitória Meller Milioli, Beatriz Sonai, Heloisa Borges, Celso Carneiro, Mariane Abatti, Iara Viana Vidigal Santana, Cleonice Michelon, and Felipe Dal-Pizzol.
• Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil; Escola superior de Criciúma-ESUCRI, Criciúma, SC, Brazil.
• Nutrition. 2020 May 1; 73: 110727.

ObjectiveThe aim of this study was to investigate the protective effects of probiotics and fecal transplantation on inflammatory and oxidative parameters in the intestines of two rat models of sepsis.MethodsRats were treated with prebiotics, probiotics, or symbiotics and exposed to lipopolysaccharide (LPS) or zymosan after 15 d to induce endotoxemia. Oxidative damage and inflammation were analyzed, and histologic examination of the intestinal tissue was performed. Fecal microbiota transplantation (FMT) was carried out in LPS- and zymosan-induced rat models of sepsis.ResultsSupplementation with symbiotics for 15 d effectively reduced the inflammatory parameters compared with supplementation for 7 d. Probiotics, prebiotics, and symbiotics exerted different effects on the evaluated parameters. In general, Lactobacillus rhamnosus and L. casei exerted better local protective effects. Evaluation of the role of the intestinal microbiota through FMT revealed its protective effects irrespective of the previous treatment with probiotics.ConclusionProbiotic strains significantly differ among themselves and exert different effects on the host's health. Symbiotics and FMT could offer additional immunomodulatory benefits to drug therapy, thus serving as a new therapeutic alternative in pediatric patients with sepsis.Copyright © 2020 Elsevier Inc. All rights reserved.

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