-
Pol. Arch. Med. Wewn. · Oct 2020
Antithrombin deficiency as a still underdiagnosed thrombophilia: a primer for internists.
- Carlos Bravo-Pérez, Maria E de la Morena-Barrio, Vicente Vicente, and Javier Corral.
- Hematology and Medical Oncology Unit, Morales Meseguer University Hospital, Regional Blood Donation Center, University of Murcia, Biomedical Research Institute of Murcia (IMIB), CIBER Rare Diseases (CIBERER), Murcia, Spain
- Pol. Arch. Med. Wewn. 2020 Oct 29; 130 (10): 868-877.
AbstractAntithrombin is a key endogenous anticoagulant that also plays other roles in inflammation, immunity, and other processes. Congenital antithrombin deficiency is the most severe type of thrombophilia, yet characterized by a remarkable clinical heterogeneity. Here, as a primer for internists, we present a practical review of data regarding this disorder, focused on its molecular basis, diagnostic procedures, prognostic implications, and clinical management of patients suffering from this severe, and probably underdiagnosed, type of thrombophilia.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..