• Pol. Arch. Med. Wewn. · Oct 2020

    Antithrombin deficiency as a still underdiagnosed thrombophilia: a primer for internists.

    • Carlos Bravo-Pérez, Maria E de la Morena-Barrio, Vicente Vicente, and Javier Corral.
    • Hematology and Medical Oncology Unit, Morales Meseguer University Hospital, Regional Blood Donation Center, University of Murcia, Biomedical Research Institute of Murcia (IMIB), CIBER Rare Diseases (CIBERER), Murcia, Spain
    • Pol. Arch. Med. Wewn. 2020 Oct 29; 130 (10): 868-877.

    AbstractAntithrombin is a key endogenous anticoagulant that also plays other roles in inflammation, immunity, and other processes. Congenital antithrombin deficiency is the most severe type of thrombophilia, yet characterized by a remarkable clinical heterogeneity. Here, as a primer for internists, we present a practical review of data regarding this disorder, focused on its molecular basis, diagnostic procedures, prognostic implications, and clinical management of patients suffering from this severe, and probably underdiagnosed, type of thrombophilia.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…