Revista da Associacao Medica Brasileira (1992)
-
Rev Assoc Med Bras (1992) · Jan 2022
Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome.
The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome. ⋯ The patients with polycystic ovary syndrome have similar rates of VEGF polymorphisms rs2010963 and rs833061 on the general population.
-
Rev Assoc Med Bras (1992) · Jan 2022
Predictive value of oxidative, antioxidative, and inflammatory status for left ventricular systolic recovery after percutaneous coronary intervention for ST-segment elevation myocardial infarction.
This study aimed to evaluate the association between left ventricular ejection fraction recovery and the total oxidant status, total antioxidant capacity, and high-sensitivity C-reactive protein levels. ⋯ Oxidative stress and inflammation parameters were detrimental to the recovery of left ventricular ejection fraction in patients with ST-elevation myocardial infarction.
-
Numerous physiological changes occur during pregnancy, which affect both the mother and the fetus. The objective of this study was to evaluate the magnesium, calcium, phosphate, parathormone (PTH), and vitamin D levels in each trimester of pregnancy. ⋯ For maintaining a healthy pregnancy and fetus, we recommend vitamin D, calcium, and magnesium levels to be included in routine follow-ups for each trimester and supplemented in case of deficiency.
-
Rev Assoc Med Bras (1992) · Jan 2022
Extended-spectrum beta-lactamases among Klebsiella pneumoniae from Iraqi patients with community-acquired pneumonia.
Beta-lactams resistance is a major clinical problem in treating pneumonia. This study aimed to detect the extended-spectrum beta-lactamases (ESBL) genes in Klebsiella pneumoniae among patients with community-acquired pneumonia (CAP) in Al-Najaf City, Iraq. ⋯ The imipenem and norfloxacin can be used in empirical treatment of K. pneumoniae isolates in Iraq. The emergence of K. pneumoniae strains harboring ESBL resistance genes necessitates the development of a regular surveillance program to prevent the spreading of these isolates more in Iraqi health care systems.
-
Rev Assoc Med Bras (1992) · Jan 2022
Investigation of allele frequencies of polymorphic variants in genes that are related to polycystic ovary syndrome.
Polycystic ovary syndrome is a hormonal disorder that normally affects women of reproductive age in the range of 18-44 years. This study aimed to investigate the allelic frequencies of two polymorphisms, IRS rs18012781 and INSR rs1799817, which are suspected to be involved in polycystic ovary syndrome. ⋯ These single-nucleotide polymorphisms do not seem to modify the risk of polycystic ovary syndrome, and they cannot be used as a marker in clinical circumstances to evaluate the possible occurrence of polycystic ovary syndrome.