Scandinavian journal of infectious diseases
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Scand. J. Infect. Dis. · Jul 2011
Meta AnalysisAssociation between lymphotoxin-α intron +252 polymorphism and sepsis: a meta-analysis.
We evaluated the association of lymphotoxin-α (LTA, also known as tumour necrosis factor-β) promoter +252 A/G polymorphism with sepsis. ⋯ The LTA +252 A/G polymorphism is associated with both susceptibility to and mortality from sepsis.
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Scand. J. Infect. Dis. · Oct 2010
Meta AnalysisThe accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: a meta-analysis.
A meta-analysis was performed to assess the accuracy of the procalcitonin (PCT) test for diagnosing neonatal sepsis. The major databases, MEDLINE, EMBASE and the Cochrane Library were searched for studies published between January 1996 and May 2009 that evaluated PCT as a diagnostic marker for neonatal sepsis and provided sufficient data to calculate sensitivity and specificity. Twenty-two studies were included in the analysis. ⋯ The PCT test showed moderate accuracy in diagnosing neonatal sepsis, regardless of differences in diagnostic criteria and time points for testing. For the diagnosis of LONS, the PCT test showed better accuracy than the CRP test. PCT is a valuable additional tool for the diagnosis of neonatal sepsis.