European journal of clinical investigation
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Eur. J. Clin. Invest. · Dec 2020
Review Meta AnalysisEffects of Exercise Programs on Pain, Disease Activity and Function in Ankylosing Spondylitis: A Meta-Analysis of Randomzied Controlled Trials.
To evaluate the effects of exercise programmes on pain, function and disease activity in patients with ankylosing spondylitis (AS). ⋯ For patients with AS, exercise programmes improve pain, function and disease activity. To confirm the results, more well-designed randomized controlled trials with large number of patients are required.
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Eur. J. Clin. Invest. · Nov 2020
Review Meta Analysis Comparative StudyEfficacy of various treatment modalities for nCOV-2019: a systematic review and meta-analysis.
Several therapeutic agents have been investigated for treatment of novel coronavirus 2019 (nCOV-2019). We conducted a systematic review and meta-analysis to assess the efficacy of various treatment modalities in nCOV-2019 patients. ⋯ Our meta-analysis suggests that except in vitro studies, no treatment has shown overall favourable outcomes in nCOV-2019 patients. Lopinavir-ritonavir, remdesivir and tocilizumab may have some benefits, while hydroxychloroquine administration may cause harm in nCOV-2019 patients. Results from upcoming large clinical trials may further clarify role of these drugs.
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Eur. J. Clin. Invest. · Nov 2020
Meta AnalysisShort-term anticoagulation after acute cardioversion of early-onset atrial fibrillation.
Controversy exists regarding anticoagulation management following acute cardioversion in patients with early-onset (<48 hours) atrial fibrillation without class I guideline indication for long-term oral anticoagulation (CHA2DS2-VASc 0-1). ⋯ Given these data, considering the bleeding risk unavoidably conferred by OAT, which is known to be higher in the first month from treatment onset, short-term anticoagulation limited to 4 weeks post-cardioversion of early-onset (<48 hours) atrial fibrillation in patients with low-moderate risk of stroke (CHA2DS2-VASc 0-1) may be omitted, at least in patients with high-bleeding risk.
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Eur. J. Clin. Invest. · Oct 2020
Review Meta AnalysisAssociation between diabetes mellitus and lung cancer: meta-analysis.
This study aimed to summarize the association between diabetes mellitus (DM) and the incidence of lung cancer using a meta-analysis of cohort studies. ⋯ This meta-analysis suggests that DM has no significant impact on the incidence of lung cancer in men but has a harmful effect on women.
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Eur. J. Clin. Invest. · Oct 2020
Meta AnalysisPredictors of Adverse Prognosis in Covid-19: A Systematic Review and Meta-analysis.
Identification of reliable outcome predictors in coronavirus disease 2019 (COVID-19) is of paramount importance for improving patient's management. ⋯ Advanced age, comorbidities, abnormal inflammatory and organ injury circulating biomarkers captured patients with an adverse clinical outcome. Clinical history and laboratory profile may then help identify patients with a higher risk of in-hospital mortality.