Medicine
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First identified in Malaysia in 1998, the Nipah virus is a paramyxovirus related to the Hendra virus. The clinical manifestation can vary from a silent infection to a life-threatening encephalitis. The World Health Organization (WHO) has documented 25 outbreaks in South Asia, resulting in 429 cases and 307 deaths to date. Currently, there are no approved treatments for the deadly Nipah virus infection, which is a serious threat to public health worldwide. Consequently, a review was conducted to examine the geographic distribution of the Nipah virus, mortality, transmission pathways, and available methods for diagnosis and treatment. ⋯ It is crucial to emphasize the importance of early Nipah virus infection diagnosis and treatment to prevent life-threatening consequences.
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This study aimed to explore the causal relationship between trace elements and osteoarthritis (OA). The results showed a relatively weak association between copper and OA, while vitamin D showed a significant positive association with OA. Mendelian randomization (MR) analysis was used to investigate the causal relationship between copper and vitamin D and OA. ⋯ Sensitivity analysis further confirmed the reliability of these causal relationships and excluded the interference of pleiotropy. These findings add to the understanding of the potential role of micronutrients in the prevention and treatment of OA and support the idea of vitamin D as a potential therapy for the prevention and treatment of OA. Future studies should further explore the specific biological mechanisms of these trace elements and the differences in their effects in different populations in order to develop more effective treatment strategies to reduce the health burden of degenerative joint diseases.
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Lung adenocarcinoma (LUAD) is a study that examines the prognostic value of lactate metabolism genes in tumor cells, which are associated with clinical prognosis. We analyzed the expression and clinical data for LUAD from The Cancer Genome Atlas database, using the GSE68465 dataset from the Gene Expression Omnibus and the MSigDB database. LASSO Cox regression and stepwise Cox regression were used to identify the optimal lactate metabolism gene signature. ⋯ High-risk samples had high tumor immune dysfunction and exclusion (TIDE) scores and low cytolytic activity (CYT) scores, indicating a poor response to ICB therapy. Similarly, most immune checkpoint molecules, immune inhibitors/stimulators, and major histocompatibility complex (MHC) molecules were highly expressed in the high-risk group. The 8-lactate metabolism gene-based prognostic model predicts patient survival, immune infiltration, and ICB response in patients with LUAD, driving the development of therapeutic strategies to target lactate metabolism.
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Colorectal cancer is a common malignant tumor with the second incidence rate and the third mortality rate worldwide. In this study, we identified and validated an immune-related gene signature, explored the clinical and molecular characteristics of the signature-defined risk groups, and assessed its ability in predicting prognosis, immune cell infiltration and immunotherapy responses. The Cancer Genome Atlas database was used as the training set while GSE39582 database as the validation set. ⋯ Signature-defined high-risk group was associated with advanced disease, poor pathological prognostic factors and less active immune infiltration microenvironment. Besides, the response to immunotherapy of high-risk group was predicted to be poorer by immunophenoscore and tumor immune dysfunction and exclusion scores. Our signature proved its efficacy in predicting prognosis, tumor immune microenvironment and responses to immunotherapy in colorectal cancer.
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Observational Study
The association of early pregnancy ultrasound parameters with reproductive hormone levels: A retrospective case-control Study.
The association between early pregnancy ultrasound parameters and reproductive hormone levels was investigated through a case-control study. Participants for this retrospective study were recruited from obstetrics and gynecology departments across multiple tertiary care centers over 2 years. Inclusion criteria for the case group included pregnant women in their first trimester with detailed ultrasound data, while the control group comprised nonpregnant women without hormonal disorders. ⋯ Prolactin levels were positively correlated with all ultrasound parameters in cases. The control group did not show any significant correlations between hormone levels and ultrasound parameters. The study concluded a significant association between early pregnancy ultrasound parameters and reproductive hormone levels in pregnant women, underscoring the potential of these hormones as biomarkers for pregnancy development.