Medicine
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This study aims to comprehensively evaluate the research landscape related to exercise and substance abuse over the past 2 decades. A systemic bibliometric analysis was conducted using 2 powerful tools, the Bibliometrix package for R and VOSviewer software. The analysis covered a corpus of literature indexed in the Web of Science's core collection. ⋯ The University of California's system has also emerged as a leading institution, fostering collaborations with diverse research entities. The most frequently recurring keywords were exercise, substance abuse, substance use disorders, mental health, and depression, among others, highlighting the research focus. This study offers insights and recommendations for future research in the area of exercise in substance abuse, emphasizing the need to explore physiological mechanisms and psychological comorbidities to optimize exercise as a therapeutic intervention.
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Neglected malleolus fracture cases, among other conditions in which arthrodesis is inevitable, usually present with pseudoarthrosis of the malleolus and impaired ligament balancing. The study aimed to summarize the clinical data results of neglected malleolus fractures accompanied by ankle instability. The retrospective study was conducted at Adana City Training and Research Hospital. ⋯ The mean Maryland Foot Scores (MFS) for preoperative, postoperative 3rd, postoperative 6th, and postoperative 12th months were 21.82 ± 6.85, 51.27 ± 15.39, 61.18 ± 20.21, and 70.82 ± 5.27, respectively. This study has shown that no matter how difficult the case, if the appropriate implant and basic arthrodesis principles are followed, the union can be achieved, albeit late, in cases with osteoarthritis due to neglected ankle malleolus fracture. Especially in the presence of infection, it should be kept in mind that union may be delayed compared to the regular arthrodesis recovery duration, requiring the team performing the surgery to be familiar with the Ilizarov technique.
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Observational Study
AMPK down-regulating Beclin-1 in prostate cancer patients with bone metastasis: An observational study.
Bone metastasis is frequently seen in patients, particularly those with prostate cancer, showing a higher hazard that deteriorates the quality of life of patients, leading to poor prognosis, which eventually causes significant mortality in prostate cancer patients. The present study investigated the mechanism of prostate cancer with bone metastasis by utilizing prostate specimens from patients. A total of 418 patients were initially enrolled for clinical analysis, including age, prostate-specific antigen (PSA) levels, body mass index (BMI), prostate magnetic resonance imaging (MRI), and bone MRI, while pathological analysis included grade group and carcinoma of the prostate. ⋯ Finally, 46 patients with prostate cancer bone metastasis (prostate cancer patients) and 61 patients with benign prostate (control group) met the inclusion criteria. We examined the expression levels of Beclin-1 and AMPK in human prostate tissues by IHC and found that Beclin-1 levels were negatively correlated with AMPK in prostate cancer with bone metastasis (P < .05). The results of this study suggest that AMPK-Beclin-1 significantly reduces prostate cancer metastasis to the bone in human tissues.
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Previous studies have demonstrated a correlation between dietary salt intake and stroke; however, there was a lack of conclusive evidence regarding a causal connection between them. We undertook a two-sample Mendelian randomization (MR) study to examine their potential association. The genome-wide data for dietary salt intake was sourced from genome-wide association study that involved 462,630 samples. ⋯ Neither Cochran Q test (P = .52) nor MR-Egger method (P = .48) found obvious heterogeneity; in addition, the MR pleiotropy residual sum and outliers global test (P = .52) and MR-Egger regression intercept (P = .74) also showed no pleiotropy. The result of our MR study showed that there was no direct causal relationship between dietary salt intake and stroke risk. More studies were required to further confirm the stability of this relationship and to trying applied the findings to the clinic.
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Observational Study
Vitality index predicts walking independence in patients with hip fracture: A retrospective study.
This study aimed to determine if the vitality index predicts walking independence in inpatients with hip fractures and calculate a cutoff value. This retrospective cohort study included inpatients with hip fracture (N = 133). Logistic regression analysis was performed with walking independence at discharge and vitality index as the dependent and independent variables, respectively, and age, Berg balance scale (BBS), knee extension muscle strength, and revised Hasegawa's dementia scale at admission as covariates. ⋯ The area under the receiver operating characteristic curve was 0.82, and the cutoff value of the vitality index at admission was 6.5 points (sensitivity, 78%; specificity, 83%). Our results suggest that the vitality index at admission can be used to predict walking independence in inpatients with hip fractures. In particular, the vitality index score ≥ 7 points at admission is a convenient index for predicting walking independence.