Neuroscience
-
Spinal cord injury (SCI) following trauma is a devastating neurological event that can lead to loss of sensory and motor functions. However, the most effective measures to prevent the spread of damage are treatment measures in the early stages. Currently, we investigated the combined effects of hyperbaric oxygen (HBO) along with epigallocatechin-3-gallate (EGCG) in the recovery of SCI in rats. ⋯ The finding indicated that the stereological parameters, antioxidant factors (CAT, GSH, and SOD), IL-10 gene expression levels and neurological functions were considerably increased in the treatment groups in comparison with control group, and these changes were more obvious in the HBO + EGCG group (P < 0.05). On the other hand, we observed that the density of apoptotic cells and gliosis, the biochemical levels of MDA and the expression levels of inflammatory genes (TNF-α and IL-1β) in the treatment groups, especially the HBO + EGCG group, were considerably reduced in comparison with control group (P < 0.05). We conclude that co-administration of HBO and EGCG has a synergistic neuroprotective effects in animals undergoing SCI.
-
Sonogenetics is preferred for neuroregulation and the treatment of brain diseases due to its noninvasive properties. Ultrasonic stimulation produces thermal and mechanical effects, among others. Since transient receptor potential vanilloid 1 (TRPV1) could be activated at 42 °C, it is overexpressed in the M1 region of the mouse motor cortex to sense the change of temperature upon being stimulated by focused ultrasound. ⋯ Furthermore, when the temperature is >42 °C, the peak-to-peak value of the EMG signal for mice with TRPV1 overexpression in the M1 region was higher than that for mice without TRPV1 overexpression. The immunohistochemical results showed that ultrasound was not harmful to the stimulation site. The noninvasive ultrasound stimulation combined with thermosensitive protein TRPV1 overexpressed in neurocytes as sonothermogenetics technology has great potential to be used for the treatment of neurological diseases.
-
Due to the increasing needs to enhance our cognitive performance, and decrease fatigue with increasing number of tasks in our everyday life, it's interesting to study whether a small amount of active substance present in dietary supplements, is enough to impact cognition. We investigated an acute effect of an energy dietary supplement containing low amount of caffeine (55 mg) and other stimulatory ingredients by means of a resting state EEG in a double blind, placebo controlled study (N = 47, 27 women). The use of a nonparametric cluster-based permutation analysis allowed us to observed a significant group × block interaction effect after 90 minutes post-ingestion (P = 0.022 cluster corrected) in the 'eyes closed' condition, i.e. an increase in normalized rsEEG power in the placebo group, which was abolished in the study group. ⋯ Similar trend but without significant effect was found in the 'eyes open' condition. Our results suggest that low caffeine content dietary supplementation acts as a reversal of the fatigue-related brain activity in the neural networks active in the resting state. These findings not only may help to clarify previous nonconclusive findings, but more importantly, show that an ingestion of caffeinated stimulants before neurocognitive examinations, both in research and diagnostics, should be taken into account, as they may influence cognition, even in small doses and when the effects are absent in the behavioral measures.
-
Age modifies walking balance and neuromuscular control. Cognitive and postural constraints can increase walking balance difficulty and magnify age-related differences. However, how such challenges affect neuromuscular control remains unknown. ⋯ Arm-crossing also reduced walking balance mostly in OA, but step speed decreased mainly in YA, in whom the margin of stability increased. Arm-crossing reduced the complexity of synergies. Age, cognitive task, and arm position affect differently muscle synergy recruitment but have similar effects on walking balance.
-
This study investigated strategies based on the reconsolidation process to promote the strengthening effect of human motor memory. The aim of this study was to evaluate the influence of reactivating the memory of a newly acquired motor skill and performing interventions during its reconsolidation process on motor performance. Sixty healthy participants learned a new Sequential Visual Isometric Pinch Task - SVIPT during the first experimental session. ⋯ All groups performed the third session to retest the learned motor skill, 24 h after session 1. The results showed that using training with moderate task variability during memory reconsolidation provides greater motor skill performance gain when compared to repetitive training of the same learned task. Furthermore, performing a session exclusively dedicated to reactivation with the practice of the originally learned task was not a determining condition for recent motor memory reactivation, but rather the induction of prediction error during the reactivation.